This baseline study could serve as a benchmark for the future sO 2 investigation of retinal macular pathologies. No significant correlation was found between sO 2 and vessel topological features, including length, diameter, and distance to fovea. Marginal correlation was found between venous sO 2 and intraocular pressure (IOP) among eyes. Arteriovenous sO 2 difference was 43.8 ± 9.5 (vol %). The arterial and venous sO 2 from all eyes was 92.1 ± 7.1 (vol %) and 48.4 ± 5.0 (vol %) (mean ± SD), respectively. In this paper, for the first time, we present a baseline study of microvascular oxygen saturation (sO 2) in perifoveal macular region using visible light optical coherence tomography (VIS-OCT) on normal eyes. The parafoveal vessels form the inner retina provide oxygen perfusion, and the measurement of parafoveal oxygen saturation (sO 2) can evaluate macular metabolism and provide pathophysiological insight. The retinal macula is at the center of our visual field, and thus pathological damage in the macula significantly impacts an individual's quality of life.
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